By searching several databases, a total of 2049 studies were retrieved, 880 duplicates were excluded, and a total of 738 studies were excluded by reading the titles and abstracts for the following reasons: Not primarily about CgA or prostate cancer, not consistent with research topic, reviews, meeting abstracts, comments, letters, and animal testing, 421 of the remaining studies were excluded because they did not discuss the relationship between CgA and prostate cancer prognosis or had no relevant outcome indicators. The gene discussed is CGA; the disease is Familial prostate cancer.