AKT1 and systemic lupus erythematosus: A significant reduction of p-STAT3+, Ki-67+, and p-Akt+CD8+ T cells was observed in 100 nM ruxolitinib-treated UCB-Tregs and SLE-PBMCs (p < 0.0001) and UCB-Treg: SLE-PBMC coculture (p < 0.01 for p-Stat3+ and p < 0.0001 for Ki-67+ and p-Akt+) (Figure 1G).