The final dataset consisted of 4825 missense variants across 26 proteins associated with primary immunodeficiencies encoded by genes: IL2RG, JAK3, RAG1, RAG2, ADA, DCLRE1C, CD40LG, WAS, ATM, STAT3, KMT2D, BTK, FOXP3, AIRE, FAS, ELANE, ITGB2, CYBB, G6PD, GATA2, STAT1, IFIH1, NLRP3, MEFV, MVK, and SERPING1 (Table 1). This evidence concerns the gene CYBB and inborn error of immunity.