At the same time, the advantage in accuracy is absolutely overwhelming for the genes GATA2, MEFV, and NLRP3, which relate with IMD21 (immunodeficiency 21, monocytopenia and mycobacterial infection syndrome), Familial mediterranean fever, and Familial cold autoinflammatory syndrome, respectively. The gene discussed is NLRP3; the disease is familial cold autoinflammatory syndrome.