At the same time, the advantage in accuracy is absolutely overwhelming for the genes GATA2, MEFV, and NLRP3, which relate with IMD21 (immunodeficiency 21, monocytopenia and mycobacterial infection syndrome), Familial mediterranean fever, and Familial cold autoinflammatory syndrome, respectively. Here, NLRP3 is linked to monocytopenia with susceptibility to infections.