Moreover, IL-10-expressing CAR T cells maintain mitochondrial structure and function in the tumor microenvironment, IL-10 secretion boosted CAR T cell proliferation and effector functions, resulting in the complete regression of established solid tumors and metastatic cancers in multiple cancer types including colon in both syngeneic and xenograft mouse models (51). This evidence concerns the gene IL10 and metastatic malignant neoplasm.