BRCA2 and breast cancer: Together with BRCA2, these genes are estimated to account for nearly 15% of familial BC cases.2 Currently, other genes associated with hereditary breast/ovarian syndrome have been identified, including those with high penetrance (PALB2, CDH1, STK11, PTEN, and TP53) and moderate penetrance (ATM, BARD1, CHEK2, RAD51C, and RAD51D).3, , , , , , , –11