AGXT2 and Cognitive impairment: For the association with 3-aminoisobutryate (beta-aminoisobutyric acid), the variants with the most statistically significant associations in the region for both FLARE3 and FLARE7 are clearly localized to the gene AGXT2, which was shown in HCHS/SOL to be associated with Mild Cognitive Impairment (MCI) in Hispanic/Latino adults, and the genetic association is mediated by the levels of beta-aminoisobutyric acid [47] (Supp.