These diseases are called tauopathies and include AD as well as several diseases under the FTLD umbrella (FTLD-tau) such as PSP, Pick’s disease, corticobasal degeneration (CBD), argyrophilic grain disease, and frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), most of which are sporadic with the exception of the latter which is caused by mutations in MAPT (such as the MAPT mutation carriers in FTLD2m) (2,68). This evidence concerns the gene MAPT and frontotemporal dementia.