STX6 and supranuclear palsy, progressive, 1: From our analysis, one CpG mapping to the promoter region of STX6 (cg02925840) was of particular interest, as it passed genome-wide significance in the FTLD3m dataset (FDR adjusted p-value = 0.002), with a strong decrease in methylation levels in the PSP cases compared to controls (delta-beta = −31.5%, Table 1, Fig. 2).