Of the 872 features calculated by SpaceCat, the most common were those capturing functional marker expression (n=347, i.e. proportion of Ki67+ cancer cells) and cellular densities (n=232, i.e. T cell density), which is a reflection of both how informative those features are (since highly correlated features are removed) and the specific markers included in our panel (Fig. 2b, Extended Data Fig. 2a). Here, MKI67 is linked to cancer.