For the naïve CD8+ T cell population, patient 2 showed a trend of having more naïve CD8+ T cells at baseline than at the end of cycle 2; however, patients 3 and 6, who had different responses, consistently displayed an opposing trend compared with patient 2, with a positive density shift for CD8-naïve T cells around leukemia cells at the end of cycle 2 from baseline (Figure 4C). The gene discussed is CD8A; the disease is leukemia.