Our application of Incytr to COVID-19 patient data, MC38, and 5XFAD mouse model data has recapitulated known biological system-specific signaling pathways such as cancer specific pathways, Alzheimer’s disease specific pathways such as Apoe-App, Apoe-Trem2, and Apoe-Lrp1. This evidence concerns the gene TREM2 and Alzheimer disease.