The 5XFAD model [Wang et al., 2015; Oakley et al., 2006] is a widely used transgenic mouse model for Alzheimer’s disease (AD), carrying five familial AD mutations—three in the amyloid precursor protein (APP) and two in the presenilin 1 (PSEN1) genes. Here, PSEN1 is linked to early-onset autosomal dominant Alzheimer disease.