21, including e.g. the superoxide dismutase 1 (SOD1) gene, genes for several interferon receptors, dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A) and regulator of calcineurin 1 (RCAN1) are known to affect AD pathology including the amyloid, phospho-tau, and neuroinflammatory and oxidative stress pathways in the brain [5,6]. The gene discussed is SOD1; the disease is Alzheimer disease.