STAT3 and neoplasm: It is noteworthy that when M2 macrophages were co-cultured with MC38 cells, the efficacy of STA in inhibiting tumor cell migration and angiogenesis was diminished following treatment with Broussonin E. This observation corroborates that STA exerts an anti-tumor effect by impeding TAMs M2 polarization through the inhibition of the JAK2/STAT3 signaling pathway.