In the aortas of patients with AD, the levels of iron-death-associated molecules, such as transferrin receptor (TFR), Heme oxygenase-1 (HO-1), and ferritin, were increased, while the levels of iron-death-regulating proteins, including SLC7A11, GPX4, and FSP1, were decreased (Figure 1) (He X. et al., 2024). This evidence concerns the gene TFRC and Alzheimer disease.