Treatment with inhibitors targeting Nox1, Nox2, and Nox4 (such as apocynin, diphenyl iodide, gp91ds-tat, and GKT137831) in a mouse model of hypertension significantly improved vascular function, normalized blood pressure, and attenuated hypertension-induced cardiac remodeling (Schröder, 2014). Here, NOX4 is linked to hypertensive disorder.