COL1A1 and cancer: Other genes, linked to cancer cell remodelling/resistance and biomechanics, with significant differential expression were elevated levels of SERPINE1 (Pan et al., 2017) and COL1A1 (collagen type I alpha one chain; An et al., 2020) in CR spheroids, demonstrating fundamental differences between P and CR SKOV3 spheroids (Figure 5B) at the transcriptomic level.