CDH2 and ovarian neoplasm: In EOC, cells initially deattach from the primary ovarian tumour through cellular EMT which loosens intercellular adhesions by downregulating the membrane glycoprotein E-cadherin (located at the cell adherent junctions), upregulating other cadherins (N-cadherin, P-cadherin), changing integrin expression and upregulation of proteolytic pathways (Lengyel, 2010).