In addition, Tenascin-C was included in the protein expression assays as recent studies have demonstrated that Tenascin-C is not only an important EMT marker in breast cancer but also has been shown to be an important tissue remodelling glycoprotein, promoting proliferation, invasion and angiogenesis, thereby contributing to tumorigenesis and metastasis (Wilson et al., 1996; 1999; Didem et al., 2014; Tucker and Degen, 2022). This evidence concerns the gene ART4 and breast carcinoma.