It binds to GU repeats of target RNAs through RRM1 and RRM256 and regulates RNA splicing and stabilization of mRNAs encoding proteins involved in neuronal survival and neurodegenerative diseases, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS).57, 58. The gene discussed is RRM1; the disease is early-onset autosomal dominant Alzheimer disease.