CRP and spondyloarthropathy: Secondly, insufficiently controlled signs and/or symptoms of disease in any of the axSpA domains (axial, peripheral, or EAMs), evaluated by parameters such as Axial Spondyloarthritis Disease Activity Score (ASDAS), elevated C-reactive protein (CRP), active inflammation on Magnetic Resonance Imaging (MRI) or rapid radiographic spinal progression (defined as development of > 2 new syndesmophytes/bony bridges in 2 years) should be documented.