MTOR and autosomal dominant disease: PHTS is a rare autosomal dominant hereditary disorder caused by germline variants of the PTEN gene located on chromosome 10q23.6,23,24)PTEN participates in the negative regulation of the phosphoinositide 3-kinase-protein kinase B and mammalian target of rapamycin signaling pathways, controlling cell proliferation and cell cycle progression and promoting apoptosis.25) Thus, the loss-of-function mutation of PTEN correlates with the development of various human cancers.