Due to the high heterogeneity of the 2 included studies (I2 = 76%, p < 0.05), a random effect model was used for data analysis, and the meta-analysis revealed this result: there was no statistically significant difference in the caspase-3 relative densities between the EA treatment group and control group, EA treatment could not reduce the caspase-3 relative densities in the animals with ischemic stroke [MD = −0.39, 95%CI (−0.79, 0.02), p > 0.05] (Supplementary Figure 1A). This evidence concerns the gene CASP3 and ischemic stroke.