The significant link of females SHBG and testosterone to AD observed in the univariable MR remained significant [SHBG-OR (95% CI): 1.005 (1.001–1.009), p = 0.023; testosterone-OR (95% CI): 0.995 (0.989–1.000), p = 0.049] after adjusting for each other. The gene discussed is SHBG; the disease is Alzheimer disease.