However, there is no evidence of a causal association of SHBG [ORs (95% CI), 1.002 (0.999–1.005), p = 0.237; Table 3] and testosterone [ORs (95% CI), 1.000 (0.997–1.004), p = 0.810; Table 3] with AD in males. Here, SHBG is linked to Alzheimer disease.