SHBG and Alzheimer disease: Using IVs to investigate the possible causal link between AD and sex hormone-related traits, the results indicate a possible causal association of SHBG [ORs (95% CI), 1.005 (1.001–1.009), p = 0.006; Table 2] and testosterone [ORs (95% CI), 0.994 (0.989–0.999), p = 0.013; Table 2] with AD in females.