NOS2 and atherosclerosis: The inducible nitric oxide synthase (iNOS) encrypted by the NOS2A gene is one of the important inflammatory mediators released by macrophages (26), the NO catalyzed by it can react with peroxy anion to form peroxynitrite, which can cause endothelial damage, promote the inflammatory reaction of vascular wall, and promote the progress and development of atherosclerosis.