PROK2 and neoplasm: Additionally, Zou et al. revealed that the overexpression of IL-35 in neutrophils, rather than exogenous IL-35, stimulated the production of G-CSF and IL-6 by neutrophils, induced polarization toward the N2 subtype associated with tumor growth, upregulated MMP-9 and Bv8 expression, downregulated TRAIL expression, and bolstered the proendothelial angiogenic capabilities of neutrophils [78].