In addition to tumor cell-derived IL-35 promoting angiogenesis, Huang et al. indicated that IL-35 originating from pancreatic ductal adenocarcinoma (PDAC) cells stimulated the GP130/STAT1 signaling pathway, resulting in the formation of p-STAT1:p-STAT4. The gene discussed is STAT4; the disease is pancreatic ductal adenocarcinoma.