Additionally, a study illustrated that upregulation of IL-35 in HepG2 cells derived from individuals with advanced hepatocellular carcinoma resulted in a notable increase in the expression levels of HLA-ABC and CD95, suppression of MMP-2 and MMP-9 activity, as well as a reduction in cell migration, invasion, and colony formation capabilities [133]. The gene discussed is MMP9; the disease is hepatocellular carcinoma.