CXCL8 and cardiac arrest: The injury activates an inflammatory response by releasing reactive oxygen species and pro-inflammatory cytokines (TNF-alpha, IL-6, IL-8, IL-1), which leads to increased vascular permeability, leukocyte demargination, and extravasation [23]. Strategies to mitigate the risk associated with intraoperative circulatory arrest times could include optimizing anesthesia management, ensuring efficient surgical techniques, and using adjunctive therapies like ECMO support when necessary.