Similarly, melanocortin-4 receptor (MC4R) agonist, setmelanotide, is effective for the treatment of genetic forms of obesity (Clément et al., 2020; Markham, 2021; Clément et al., 2018; Haws et al., 2020). The gene discussed is MC4R; the disease is obesity due to melanocortin 4 receptor deficiency.