ATXN1 and neurodegenerative disease: Spinocerebellar ataxia type 1 (SCA1), spinocerebellar ataxia type 2 (SCA2) and Huntington disease are autosomal-dominant genetically determined neurodegenerative diseases, caused by the expanded CAG repeats (polyglutamine, polyQ) at the ATXN1, ATXN2 and HTT genes, respectively.