MAPT and Alzheimer disease: In Alzheimer’s disease, amyloid-β induces glutamate release from both neuronal and glial cells to cause a slow buildup of extracellular glutamate (Li et al., 2011; Talantova et al., 2013) that activates extrasynaptic NMDARs to further increase amyloid-β production (Bordji et al., 2010) and tau over-expression (Sun et al., 2016), indicating an important role for glutamate excitotoxicity mediated by extrasynaptic NMDARs in exacerbating AD pathogenesis.