No homozygous P/LP variants were observed (Figure S2D); however, in addition to the CMMRD patient with compound heterozygous MSH6 variants, a patient with medulloblastoma (MB, PT_2FK75B27) had two adjacent PMS2 P/LP InDels on the same allele (Figure S2E), despite no reported CPS. Here, PMS2 is linked to medulloblastoma.