P/LP carriers were non-randomly distributed across histologies (p=5.0e-4, Table 1), and enriched in neurofibroma plexiform (NF; n=11/15, OR=9.5, 95% CI=2.7-41.0, p=4.6e-06) and HGG (n=26/76, OR=1.8, 95% CI=1.1-3.2, p=0.02) cohorts (Figure 2E, Figure S3A). Here, NFASC is linked to plexiform neurofibroma.