A germline LZTR1 stop gained P/LP carrier with schwannoma (PT_BWFTKJXT) exhibited increased intron 14 retention directly upstream of this variant that was associated with significant transcript loss relative to other schwannomas (R=−0.71, p=9.5e-3; Figure 4E,G), suggesting a mechanism of LZTR1 inactivation. This evidence concerns the gene LZTR1 and schwannoma.