For example, cg03586820 (SZRD1) was among the ten most significant CpG sites for tTau, pTau and Aβ42/tTau, and cg13422045 (ARHGEF17) also showed similar associations across the tau-related CSF AD biomarkers (tTau, pTau and pTau+/−). This evidence concerns the gene ARHGEF17 and Alzheimer disease.