In the EWAS of the White EHBS participants (N=450), no CpG sites were significant at the Bonferroni adjusted p-value<0.05 threshold (equivalent to p< 7.56 × 10−8) for any of the AD CSF biomarkers after adjusting for age, sex, smoking history, and estimated cell-type proportions (B lymphocytes, natural killer cells, CD4 + T lymphocytes, CD8 + T lymphocytes, monocytes, neutrophils) (Figure 1, Table 2, Figure S1). This evidence concerns the gene CD4 and Alzheimer disease.