CD8A and Alzheimer disease: In the EWAS meta-analysis of the White EHBS and ADNI participants (N=572), no CpG sites were significant at the Bonferroni adjusted p-value<0.05 threshold (equivalent to p< 7.60 × 10−8) for any of the AD CSF biomarkers after adjusting for age, sex, smoking history, and estimated cell-type proportions (B lymphocytes, natural killer cells, CD4 + T lymphocytes, CD8 + T lymphocytes, monocytes, neutrophils) (Table 3, Figure S3, Figure S4).