Herpesvirus infection is lifelong and highly host-specific, to resist virus invasion, hosts use pattern recognition receptors (PRRs), such as retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5), to recruit a series of signal transduction molecules, such as stimulator of interferon genes (STING) and mitochondrial antiviral signaling protein (MAVS). The gene discussed is RIGI; the disease is Herpesviridae infectious disease.