Yet, recent systematic reviews and meta-analyses revealed that routine rapid viral testing was primarily associated with higher influenza antiviral use.9,10 One possible explanation for these findings is clinician hesitation to avoid prescribing antibiotics for viral infections, given that up to 40% of such cases may involve bacterial coinfections.11 Beside pathogen-based testing strategies, inflammatory biomarkers, such as C-reactive protein (CRP) and procalcitonin (PCT), are widely incorporated into routine clinical practice. This evidence concerns the gene CRP and influenza.