The production of Th1 cytokines (IL-2 and IFN-γ) by CARζ/CPR41BB cells (n = 3) was lower at 24 hours after coculture with LN229-GBM cells compared with both CAR41BBζ and CAR28ζ (**, P < 0.000; ****, P < 0.0001; Two-way ANOVA with the Tukey test; Fig. 5A). Here, IFNG is linked to glioblastoma.