In the CARIS with both WT and PD-L1 KO LN229-GBM, the recruitment of CPR increased over time, but the intensity was found to be dependent on the expression of PD-L1 on tumor targets (P = 0.99 at 15 minutes, P = 0.004 at 30 minutes, P = 0.007 at 60 minutes, Kruskal–Wallis and Wilcox pairwise; Fig. 5G). This evidence concerns the gene CD274 and neoplasm.