At 24 hours of coculture with autologous GBM, we observed a consistent pattern across all patient donors (n = 5), wherein CPR/CART demonstrated greater IFN-γ release over CAR28ζ, but with a marked difference between CARζ and CAR28ζ cells coexpressing CPR28 (one-way ANOVA with the Tukey test; Fig. 3B). The gene discussed is IFNG; the disease is glioblastoma.