CARζ/CPR41BB cells showed differential expansion of the central memory (CCR7+/CD45RA−) compartment after prolonged tumor encounter compared with all other CART cells (*, P < 0.05; **, P < 0.01, one-way ANOVA with the Dunnett test; Fig. 4F and G; Supplementary Fig. S5D), whereas the proportion of CAR+CD8+ effector memory T cells differed between CARζ/CPR41BB and CAR28ζ/CPR28 but not with others (*, P < 0.05, one-way ANOVA with the Dunnett test; Fig. 4H). This evidence concerns the gene CD8A and neoplasm.