For example, while genetic BLT1 depletion in mouse models of lung cancer was shown to reduce neutrophil infiltration and tumor growth, in several cancer models (with subcutaneous implantation of cervical, melanoma, and breast cancer cells), the absence of BLT1 reduced tumor infiltration of antitumor CD8 T cells with a subsequent increase in tumor progression [171, 172]. The gene discussed is LTB4R; the disease is breast carcinoma.