For example, while genetic BLT1 depletion in mouse models of lung cancer was shown to reduce neutrophil infiltration and tumor growth, in several cancer models (with subcutaneous implantation of cervical, melanoma, and breast cancer cells), the absence of BLT1 reduced tumor infiltration of antitumor CD8 T cells with a subsequent increase in tumor progression [171, 172]. This evidence concerns the gene LTB4R and melanoma.