Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) is the first reported specific and selective inhibitor of GLS1, including KGA and GAC, which induces cell death by inhibiting glutamine uptake in cancer cells (Jeong et al., 2013; Robinson et al., 2007). Here, GLS is linked to cancer.