In vivo lung cancer metastasis model established in BALB/c mice with orthotopic breast tumors, knocking down SLC7A5 led to a reduction in tumor weight and volume, inhibited lung tumor lesion formation, and reduced the abundance of CD4+ T and CD8+ T cells, indicating that inhibiting SLC7A5 alleviated immune suppression (Huang et al., 2023). The gene discussed is SLC7A5; the disease is breast neoplasm.