GLS and breast cancer: When breast cancer cells with high GLS2 expression and low GLS1 expression are injected into the flanks of NOD/SCID mice, there is a significant increase in the number of metastatic lesions in the lungs, indicating that GLS2 may promote breast cancer metastasis, potentially dependent on low GLS1 levels, although the specific mechanism remains unclear (Dias et al., 2020).