ANGPTL4 and androgen insensitivity syndrome: 2019). The observed pattern in the ANGPTL4 level mirrors the postischemic changes in BBB dysfunction (Bernardo‐Castro et al. 2020). In AIS, peaks in BBB permeability typically occur during the hyperacute stage (less than 6 h) and the acute stage (6–72 h; Strbian et al. 2008; Pillai et al. 2009; Lin et al. 2008, Durukan et al. 2009).