In the present study, KEGG analysis was performed on the co‐expressed genes of FAM30A and several signalling pathways including B‐cell receptor signalling pathway, T‐cell receptor signalling pathway, NF‐кB signalling pathway, JAK–STAT signalling pathway, and Ras signalling pathway was found, which were consistent with the analysis of tumour immune microenvironment of CRC. This evidence concerns the gene PPIB and colorectal carcinoma.