It combats viral infections via direct binding to viral RNA and the recruitment of the cellular mRNA decay machinery, including tripartite motif containing 25 (TRIM25), KH and NYN domain-containing (KHNYN), p72 RNA helicase, the 5′-3′ exoribonuclease XRN1, and the 3′-5′ RNA exosome complex, to degrade the viral RNA transcripts [4–7]. The gene discussed is TRIM25; the disease is viral infectious disease.