In contrast with the antiviral mechanism of ZFP36L1 against flaviviruses in which ZFP36L1 recruits both the 5′-3′ XRN1 and 3′-5′ RNA exosome pathways to degrade flavivirus RNA, ZFP36L2 impedes flavivirus infection through a 5′-3′ XRN1-mediated RNA decay pathway. Here, XRN1 is linked to Flavivirus Infections.