The inhibition of the PI3K/AKT/mTOR pathway not only restores apoptotic signaling in tumor cells but may also promote the release of apoptosis-related signaling molecules, such as DAMPs and HMGB1, and pro-inflammatory cytokines, such as IL-12 and IFN-γ, which activate anti-tumor immune responses. This evidence concerns the gene AKT1 and neoplasm.