The inhibitor attenuates 6-OHDA mediated cell death of nigral-dopaminergic neurons in PD mice, which improves motor performance and recovery of dopamine and two synaptic proteins, VAMP (Vesicle-associated membrane protein 2) and SNAP25 (Synaptosomal-Associated Protein, 25 kDa) [157]. The gene discussed is SNAP25; the disease is Parkinson disease.