Other known factors that disturb mitochondrial homeostasis in PD include disruption of retromer complex which results in mitochondrial fragmentation due to mutation in VPS35 gene [167]; deficiency of mitochondrial protein kinase; and PTEN-induced putative (PINK)1 which is associated with an autosomal recessive variant (PARK6) of PD [168]. This evidence concerns the gene VPS35 and Parkinson disease.