To further investigate the in vivo impact of MMP28 on pancreatic cancer progression and TAM infiltration, BxPC-3 cells with MMP28 knockdown (sh-MMP28) and control BxPC-3 cells (sh-NC) were subcutaneously injected into BALB/c nude mice to establish pancreatic cancer xenograft models. This evidence concerns the gene MMP28 and familial pancreatic carcinoma.