RTN3 and pulmonary fibrosis: To indicate the relationship between RTN3 and pulmonary fibrosis, we then generated the RTN3-null mice (Fig. 2A). The RTN3-null mice (n = 6) and Wild type control littermates (n = 6) aged 8 weeks were selected to establish pulmonary fibrosis mice model by endotracheal instillation of bleomycin.