TFEB and Alzheimer disease: Our previous clinical study identified alterations in mitophagy biomarkers across the AD continuum, with increased CSF and serum levels of PTEN-induced Kinase 1 (PINK1) and serum BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) (mitophagy activators) and decreased serum levels of transcription factor EB (TFEB) (a master regulator of lysosomal biogenesis) in AD dementia compared to controls [4].