We observed that only CRC cells with HNRNPA2B1 expression knocked down presented clearly decreased expression levels of MIR181A1HG in EVs rather than total MIR181A1HG (Fig. 3b-e; Supplementary Fig. S6a-e), whereas the expression levels of HNRNPA2B1 in the four CRC cell lines HT29, RKO, SW480, and SW620 did not significantly differ (Supplementary Fig. S6f). This evidence concerns the gene MIR181A1HG and colorectal carcinoma.