The results revealed more liver metastases and poorer OS following the injection of EVs derived from highly metastatic CRC cells than from the injection of EVs derived from weakly metastatic CRC cells, while the overexpression or knockdown of MIR181A1HG in CRC cell-derived EVs could partially strengthen or attenuate the promoting effects of CRC cell-derived EVs on CRLM (Fig. 2c-e, Supplementary Fig. S4c). Here, MIR181A1HG is linked to colorectal carcinoma.