MIR181A1HG and colorectal carcinoma: We also assessed MIR181A1HG expression in EVs from serum samples from the same CRC cohorts and 40 healthy donors and discovered that MIR181A1HG expression was obviously elevated in EVs derived from CRC patients compared with those from healthy donors (Fig. 1d), and its expression was also obviously greater in EVs derived from CRC patients at stages III-IV than in EVs derived from CRC patients at stages I-II (Fig. 1e).