MIR181A1HG and cancer: To investigate the effects of MIR181A1HG in CRC cell-derived EVs on cancer biological processes in CRLM, the CRC cell line HT29/RKO was transfected with MIR181A1HG overexpression or knockdown plasmids, and then EVs were extracted and cocultured with another CRC cell line, HCT8.