To further explore the role of MIR181A1HG in the progression of CRLM, we first measured MIR181A1HG expression in the conditioned medium (CM) of seven CRC cell lines and found that the expression levels of MIR181A1HG in the CM of HT29 and SW480 cells were relatively low, whereas the expression levels of MIR181A1HG in the CM of RKO and SW620 cells were relatively high (Fig. 2a). The gene discussed is MIR181A1HG; the disease is colorectal carcinoma.