We observed that only CRC cells with HNRNPA2B1 expression knocked down presented clearly decreased expression levels of MIR181A1HG in EVs rather than total MIR181A1HG (Fig. 3b-e; Supplementary Fig. S6a-e), whereas the expression levels of HNRNPA2B1 in the four CRC cell lines HT29, RKO, SW480, and SW620 did not significantly differ (Supplementary Fig. S6f). The gene discussed is HNRNPA2B1; the disease is colorectal carcinoma.