In our study, we found that CXCL12 expression was apparently upregulated in HSCs activated by MIR181A1HG in CRC cell-derived EVs and that activated HSCs promoted CRLM by secreting CXCL12 to remodel the ECM and recruit MDSCs in liver metastases. The gene discussed is CXCL12; the disease is colorectal carcinoma.