A significant inverse correlation was observed between eGFR and multiple AD biomarkers, including Aβ42 (rho = -0.23, p = 2e-04), Aβ40 (rho = -0.43, p < 1e-04), p-tau181 (rho = -0.22, p = 3e-04), p-tau217 (rho = -0.34, p < 1e-04), p-tau231 (rho = -0.24, p < 1e-04), NfL (rho = -0.52, p < 1e-04), and GFAP (rho = -0.40, p < 1e-04) (Fig. 2a). This evidence concerns the gene NEFL and Alzheimer disease.