Our previous data have suggested the positive correlation between Nedd4 and RORγt expression in CD4+T cells of MS patients (Fig. 1F) and the effect of Nedd4 knockout in RORγt expressing CD4+ T cells of EAE on Th17 cell response (Fig. 2I, J), which suggest that Nedd4 is closely related to RORγt in CD4+ T cells. Here, NEDD4 is linked to myeloid sarcoma.