BCR and autoimmune polyendocrinopathy: In a comprehensive perspective of the reference indicators for immunotherapy recruited from Thorsson and his collegues(Thorsson et al. 2018), TIS, APS, TCR.Shannon, BCR.Shannon, and Lymphocytic Infiltration Scores were significantly higher in Subtype 2, suggesting patients represented by Subtype 2 may response better to immunotherapy (Fig. 4E-G, Supplementary Fig. 2E-F).