AKT1 and cancer: AKT, a serine/threonine kinase, is the central factor in PI3K mediated radioresistance both in vivo and in vitro, and the PI3K/AKT signaling pathway has been shown to facilitate the repair of IR-induced DSBs (Florczak et al. 2009), the inhibition of autophagy, and the maintenance of the stemness of cancer cells (Chen et al. 2023).