We treated cohort 23 (Ctnnb1ex3/WTR26LSL-MYC/LSL-MYCPtenfl/flTrp53R172H/WTCdkn2aKO/KO) mice, representing HuMo cluster 4, and cohort 45 (R26LSL-MYC/LSL-MYCKrasG12D/WT) mice (induced with a higher titre of AAV.TBG.cre than cohort 32 to increase tumour burden to make survival time comparable to cohort 5), representing HuMo cluster 2 (Fig. 5b). The gene discussed is MYC; the disease is neoplasm.