To determine whether genes involved in GABAergic synaptic transmission are expressed in high-grade gliomas, we analysed single-cell RNA sequencing (RNA-seq) datasets15,32 from the malignant cells of primary patient tumour samples of H3K27M+ DMG, isocitrate dehydrogenase (IDH) wild-type (WT) hemispheric high-grade glioma, IDH-mutant hemispheric high-grade glioma and tumour-associated non-malignant oligodendrocytes. This evidence concerns the gene IDH3A and central nervous system cancer.