We observed a decrease in body weight (Supplementary Fig. 3K), an increase in liver-body weight ratio (Supplementary Fig. 3L), elevated serum levels of ALT, AST, TBIL, and DBIL (Supplementary Fig. 3M), increased tumor nodules and numbers (Fig. 1K and Supplementary Fig. 3N), as well as significant ductular reaction and larger tumor area (Fig. 1L and Supplementary Fig. 3O) in TAA-treated mice, confirming successful induction of the ICC model. The gene discussed is GPT; the disease is intrahepatic cholangiocarcinoma.