MANF and neoplasm: MANF KO mice exhibited smaller liver size, less tumor number and area (Fig. 3J, K and Supplementary Fig. 6F, G), lower liver-body weight ratio (Fig. 3L), and poorer serum levels of ALT, AST, TBIL, and DBIL (Fig. 3M) than KOfl/fl mice under SBT induction, which was opposite to MANF KI mice.