While TVB-3166 did not affect the tumor spectrum in p53R172H/R172H mice (mainly lymphomas and sarcomas; Supplementary Table 1), TVB-3166 suppressed tumorigenesis and significantly extended the lifespan in p53R172H/R172H mice but not p53−/− mice (Fig. 6l). The gene discussed is TP53; the disease is sarcoma.