Numerous studies have demonstrated that many missense mutant p53 (mutp53) proteins not only lose the function of wild-type p53 (wtp53) in tumor suppression due to the inability to bind to p53REs in target genes, but also gain new oncogenic activities to promote tumorigenesis independently of wtp53, termed as the gain-of-function (GOF) of mutp533–13. Here, TP53 is linked to neoplasm.