FASN and cancer: Positive p53 staining was observed in 78.3% of TNBC (144 out of 184) and 53.7% of colorectal tumors (158 out of 294), respectively, and a very significant correlation between the high levels of FASN and p53 were found in TNBC and colorectal tumor tissues (Fig. 7d, e), suggesting that FASN overexpression is an important mechanism for mutp53 protein accumulation in cancers.