ICAM1 and neoplasm: Strikingly, our immunoblot results (Fig. 4i and Supplementary Fig. 7) revealed that mouse TANs (T1 and T2) also express high levels of Cathepsin B, the major protease cleaving peptide linkers of ICAM1-ADCs, in comparison with peripheral neutrophils (P1 and P2), indicating that TANs could cleave intact ICAM1-ADCs into small molecular payloads and subsequently exert the bystander killing effect, as well as antigen-positive tumor cells in TME, leading to enhanced an amplified antitumor activity of ICAM1-ADCs.